Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés

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Laboratoire d'Ecologie des Hydrosystèmes
Naturels et Anthropisés

STIER Antoine

Post-doctorant : E2C

Université Lyon 1
Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés
6, rue Raphaël Dubois - Bât. Forel
F-69622 Villeurbanne Cedex FRANCE


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  • « Ecophysiologie du stress et du vieillissement » : ma recherche est à l’interface entre la physiologie, l’écologie et la gérontologie. Je m’intéresse à comprendre l’impact des conditions environnementales sur des mécanismes physiologiques liés au vieillissement, mais également à comprendre comment ces mécanismes physiologiques peuvent façonner le phénotype des animaux tout au long de leur vie.

    Ma recherche est centrée sur le rôle du fonctionnement mitochondrial, du stress oxydant, des hormones glucocorticoides et de l’érosion des télomères comme des mécanismes proximaux potentiels façonnant la santé, le vieillissement et les traits d’histoires de vie. J’utilise principalement des modèles aviaires, aussi bien en captivité qu’en milieu naturel.

    « Physiological Ecology of Ageing » My research is at the crossroad between physiology, ecology and gerontology. I am broadly interested in understanding the impact of environmental conditions on physiological mechanisms contributing to the ageing process, and how such processes shape organism’s phenotype from the conception to the death.

    My research focus on the contribution of mitochondrial function, oxidative stress, stress hormones and telomere dynamics as proximate mechanisms shaping health, ageing and life histories. I use mainly bird species as models, both in captivity and in their natural environment.

  • Sous Presse Kärkkäinen, T., Laaksonen, T., Burgess, M., Cantarero, A., Martínez‐padilla, J., Potti, J., Moreno, J., Thomson, R.L., Tilgar, V., Stier, A. Population differences in the length and early‐life dynamics of telomeres among European pied flycatchers. Molecular Ecology. ⟨10.1111/mec.16312⟩

    Sous Presse Montoya, B., Tóth, Z., Lendvai, A., Stier, A., Criscuolo, F., Zahn, S., Bize, P. Does IGF-1 shape life-history trade-offs? Opposite associations of IGF-1 with telomere length and body size in a free-living bird. Frontiers in Ecology and Evolution, ⟨10.3389/fevo.2022.853674⟩

    2022 Cossin-Sevrin, N., Hsu, B.Y., Marciau, C., Viblanc, V.A., Ruuskanen, S., Stier, A., 2022 - Effect of prenatal glucocorticoids and thyroid hormones on developmental plasticity of mitochondrial aerobic metabolism, growth and survival: an experimental test in wild great tits Journal of Experimental Biology, 225, jeb243414. ⟨10.1242/jeb.243414⟩

    2022 Ruuskanen, S., Hukkanen, M., Garcin, N., Cossin-Sevrin, N., Hsu, B.Y., Stier, A., 2022 - Altricial Bird Early-Stage Embryos Express the Molecular “Machinery” to Respond to and Modulate Maternal Thyroid Hormone Cues. Physiological and Biochemical Zoology, 95 (6), pp.544-550. ⟨10.1086/721556⟩

    2022 Stier, A., Monaghan, P., Metcalfe, N., 2022 - Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood. Proceedings of the Royal Society. B, Biological Sciences, 289, pp.20212679. ⟨10.1098/rspb.2021.2679⟩


    • List of published work

    Contributions of students I supervised are highlighted in green. Articles coming from projects I led as PI or co-PI (i.e. not being supervised) have their n° highlighted in red.

    1st or last authored papers (28):

    28- Stier A, Monaghan P & Metcalfe NB. Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood (2021).  bioRxiv

    27- Kärkkäinen T, Laaksonen T, Burgess M, Cantarero A, Martinez-Padilla J, Potti J, Moreno J, Thomson RL, Tilgar V & Stier A. Population differences in the length and early-life dynamics of telomeres among European pied flycatchers (2021). Molecular Ecology (in press)

    26- Kärkkäinen T, Briga M, Laaksonen T & Stier A. Within-individual repeatability of telomere length: a meta-analysis in non-mammalian vertebrates (2021). Molecular Ecology

    25- Koch R, Buchanan K, Casagrande S, Crino O, Dowling D, Hill G, Hood W, McKenzie M, Mariette M, Noble D, Pavlova A, Seebacher F, Sunnucks P, Udino E, White C, Salin K* & Stier A* (joint last authors; 2021). Integrating mitochondrial aerobic metabolism into Ecology and Evolution. Trends in Ecology & Evolution 36, 321-330 (x citations).

    24- Stier A. (2021) Human blood contain cell-free mitochondria, but are they really functional? American Journal of Physiology-Endocrinology and Metabolism 320 (5), E859-E863

    23- Stier A, Bize P, Massemin S & Criscuolo F (2021). Long-term intake of the illegal diet pill DNP reduces lifespan in a captive bird model. Comp Biochem Physiol Part C 242, 108944

    22- Kärkkäinen T, Teerikorpi P, Schuett W, Stier A* & Laaksonen T* (joint last authors; 2021). Interplays between pre- and post-natal environments affect early-life mortality, body mass and telomere dynamics in the wild. Journal of Experimental Biology 224, jeb231290 (x citations)

    21- Stier A, Hsu B-Y, Marciau C, Doligez B, Gustafsson L, Bize P & Ruuskanen S (2020). Born to be young?   Prenatal thyroid hormones increase early-life telomere length in wild collared flycatchers. Biology Letters 16, 20200364

    20- Hsu B-Y, Sarraude T, Cossin-Sevrin N, Crombecque M, Stier A* & Ruuskanen S* (joint last authors; 2020). Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation. Scientific Reports 10, 14563 (1 citation)

    19- Kärkkäinen T, Bize P & Stier A (2020). Correlation in telomere length between feathers and blood cells in pied flycatchers. Journal of Avian Biology, 51(4) (2 citations)

    18- Stier A, Metcalfe NB, & Monaghan P (2020). Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird. Proceedings of the Royal Society B 287, 20201378 (2 citations)

    17- Stier A, Bize P, Hsu B-Y & Ruuskanen S (2019). Plastic but repeatable: rapid adjustments of mitochondrial function and density during reproduction in a wild bird species. Biology Letters 15, 20190536 (6 citations)

    16- Stier A, Bize P, Haussmann M, Roussel D, Robin JP & Viblanc V (2019). Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress. Scientific Reports 9, 8545 (12 citations)

    15- Reichert S & Stier A (2017). Does oxidative stress shorten telomeres? A review. Biology Letters 13 (95 citations)

    14- Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D & Bize P (2017). How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods in Ecology and Evolution 8, 1172-1182 (18 citations)

    13- Marasco V*, Stier A* (joint 1st authors), Boner W, Griffiths K, Heidinger B & Monaghan P (2017). Environmental conditions can modulate the links among oxidative stress, age and longevity. Mechanisms of Ageing and Development 164, 100-107 (18 citations)

    12- Stier A*, Dupoué A* (joint 1st authors), Angelier F, Picard D, Brischoux F & Lourdais O (2017). Oxidative stress in a capital breeder (Vipera aspis) facing pregnancy and water constraints. Journal of Experimental Biology 220, 1792-1796 (14 citations)

    11- Simide R, Angelier F, Gaillard S & Stier A (2016). Age and heat stress as determinants of telomere length in a long-lived fish, the Siberian sturgeon. Physiological & Biochemical Zoology 89, 441-447 (34 citations)

    10- Stier A, Delestrade A, Pierre Bize, Zahn S, Criscuolo F & Massemin S (2016). Investigating how telomere dynamics, growth and life-history covary along an elevation gradient in two passerine species. Journal of Avian Biology 47, 134-140 (28 citations)

    9- Stier A, Reichert S, Criscuolo F & Bize P (2015). Red blood cells open promising avenues for longitudinal studies of ageing in laboratory, non-model and wild animals. Experimental Gerontology 71, 118-134 (54 citations)

    8- Stier A, Tissier M, Criscuolo F & Massemin S (2015). Starting with a handicap: Effects of hatching asynchrony on growth rate, oxidative stress and telomere dynamics in free-living great tits. Oecologia 179, 999-1010 (48 citations)

    7- Stier A, Bize P, Habold-Oudart C, Massemin S & Criscuolo F (2014) Mitochondrial uncoupling prevents cold-induced oxidative stress: a case study using UCP1 knock-out mice. Journal of Experimental Biology 217, 624-630 (73 citations)

    6- Stier A, Viblanc V, Massemin S, Handrich Y, Zahn S, Rojas E, Saraux C, Le Vaillant M, Prud’homme O, Grosbellet E, Robin JP, Bize P & Criscuolo F (2014). Starting with a handicap: phenotypic differences between early- and late-born king penguin chicks and their survival correlates. Functional Ecology 28, 601-611 (49 citations)

    5- Stier A, Delestrade A, Zahn S, Arrivé M, Criscuolo F & Massemin S (2014). Elevation impacts the balance between growth and oxidative stress in coal tits. Oecologia 175, 791-800 (24 citations)

    4- Stier A, Massemin S & Criscuolo F (2014). Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds. Journal of Comparative Physiology B 184, 1021-1029 (31 citations)

    3- Stier A, Bize P, Roussel D, Schull Q, Massemin S & Criscuolo F (2014). Mitochondrial uncoupling as a regulator of life history trajectories in birds: An experimental study in the zebra finch. Journal of Experimental Biology 217, 3579-3589 (27 citations)

    2- Stier A, Bize P, Schull Q, Zoll J, Singh F, Geny B, Gros F, Royer C, Massemin S & Criscuolo F (2013) Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing. Frontiers in Zoology 10, 33 (70 citations)

    1- Stier A, Reichert S, Massemin S, Bize P & Criscuolo F (2012) Constraint and cost of oxidative stress on reproduction - correlative evidence in laboratory mice and review of the literature. Frontiers in Zoology  9, 37 (116 citations)


    Co-authored papers (16):

    16- Ton R, Stier A, Cooper C & Griffith SC (2021). Effects of heat waves during postnatal development on mitochondrial and whole body physiology: an experimental study in zebra finches. Frontiers in Physiology 12, 554

    15- Casagrande S, Stier A, Monaghan P, Loveland JL, Boner W, Lupi S, Trevisi R, & Hau M (2020). Increased glucocorticoid concentrations in early-life cause mitochondrial inefficiency and short telomeres. Journal of Experimental Biology 223, 222513 (1 citation)

    14- Viblanc VA, Schull Q, Stier A, Durand L, Lefol E, Robin JP, Zahn S, Bize P, & Criscuolo F (2020). Foster rather than biological parental telomere length predicts offspring survival and telomere length in king penguins. Molecular Ecology 29, 3154-3166 (1 citation)

    13- Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, ..., Stier A, ..., Zorzano A & Zvejniece L (2019). Mitochondrial respiratory states and rates. Bioenergetics Communications doi:10.26124/mitofit:190001.v2 (16 citation)

    12- Majer AD, Fasanello VJ, Tindle K, Frenz BJ, Ziur AD, Fisher CP, Fletcher KL, Seecof OM, Gronsky S, Vassallo BG, Reed WL, Stier A & Haussmann MF (2019). Is there an oxidative cost of acute stress? Characterization, implication of glucocorticoids and modulation by prior stress experience. Proceedings of the Royal Society B 286, 20191698 (4 citation)

    11- Kärkkäinen T, Teerikorpi P, Panda B, Helle S, Stier A & Laaskonen T (2019). Impact of continuous predation threat on telomere dynamics in parent and nestling pied flycatchers. Oecologia 191, 757-766 (6 citations)

    10- Viblanc VA, Schull Q, Cornioley T, Stier A, Ménard JJ, Groscolas R & Robin JP (2018). An integrative appraisal of the hormonal and metabolic changes induced by acute stress using king penguins as a model. General and Comparative Endocrinology 269, 1-10. (7 citation)

    9- Viblanc VA, F. Dobson S, Stier A, Saraux C, Schull Q, Gineste B, Kauffmann M, Massemin S, Pardonnet S, Robin JP, Criscuolo F and Bize P (2016). Mutually honest? Physiological ‘qualities’ signaled by color ornaments in a monomorphic seabird. Biological Journal of the Linnean Society 118, 200-214 (14 citations)

    8- Schull Q, Dobson SF, Stier A, Criscuolo F, Lefol E, Saadaoui H, Robin JP, Bize P & Viblanc VA (2016). Beak color dynamically signals changes in fasting status and parasite loads in king penguins (Aptenodytes patagonicus). Behavioral Ecology 27, 1684-1693 (12 citations)

    7- Schull Q, Viblanc VA, Stier A, Saadaoui H, Lefol E, Criscuolo F Bize P & Robin JP (2016). The oxidative debt of fasting: evidence for short to medium-term costs of advanced fasting in adult king penguins. Journal of Experimental Biology 219, 3284-3293 (19 citations)

    6- Speakman J, Blount J, Bronikowski A, Buffenstein S, Isaksson C, Kirkwood T, Monaghan P, Ozanne S, Beaulieu M, Briga M, Carr S, Christensen L, Cochemé H, Cram D, Dantzer B, Harper J, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons M, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M & Selman C (2015). Oxidative stress and life histories: unresolved issues and current needs. Ecology & Evolution 5, 5745-5757 (129 citations)

    5- Reichert S, Stier A, Zahn S, Bize P, Massemin S & Criscuolo F (2014). Increased brood size leads to persistent eroded telomeres. Frontiers in Ecology & Evolution 2, 9 (57 citations)

    4- Viblanc VA, Gineste B, Stier A, Robin JP & Groscolas R (2014). Stress hormones in relation to breeding status and territory location in colonial king penguin: a role for social density? Oecologia 175, 763-772 (20 citations)

    3- Plumel M, Stier A, Thiersé D, Van Dorsselaer A, Criscuolo F & Bertile F (2014). Litter size manipulation in laboratory mice: an example of how proteomic analysis can uncover new mechanisms underlying the cost of reproduction. Frontiers in Zoology 11, 41 (20 citations)

    2- Lehto Hürlimann M, Stier A, Scholly O, Criscuolo F & Bize P (2014). Short- and long-term effects of litter size manipulation in wild-derived common voles. Biology Letters 10, 20131096 (7 citations)

    1- Geiger S, Le Vaillant M, Lebard T, Reichert S, Stier A, Le Maho Y, Criscuolo F (2012). Catching-up but telomere loss: half-opening the black box of growth and ageing trade-off in wild king penguin chicks. Molecular Ecology 21, 1500-1510 (123 citations)

Site de la Doua
Université Claude Bernard - Lyon I
CNRS, UMR 5023 - LEHNA (Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés)
3-6, rue Raphaël Dubois - Bâtiments Darwin C & Forel, 69622 Villeurbanne Cedex
43, Boulevard du 11 novembre 1918
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Tél. : (33) 4 72 43 29 53 - Fax : (33) 4 72 43 11 41
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CNRS, UMR 5023 - LEHNA (Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés)
3, rue Maurice Audin
69518 Vaulx-en-Velin
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Tél : (33) 04 72 04 70 56 - Fax : (33) 04 72 04 77 43