Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés

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Laboratoire d'Ecologie des Hydrosystèmes
Naturels et Anthropisés


Enseignant chercheur : E2C
Responsable EBO : Pôle Pédagogique EBO
Responsable scientifique : ACSED (FR BioEnVIS)

Université Lyon 1
Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés
3, rue Raphaël Dubois - Bât. Darwin C
F-69622 Villeurbanne Cedex FRANCE

(+33) 04 72 43 15 20 (+33) 04 72 43 11 41

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- Ecophysiologiste
- Professeur des Universités

  • Research area:Physiological Ecology; Cellular Bioenergetics and individual performances; Thermobiology, Sexual Selection

    image1voituronI try to understand the physiological mechanisms involved in the trade-offs organization between life history traits through three physiological processes that are the oxygen consumption, ATP production and the production of free radicals (Reactive Oxygen Species: ROS). While ATP is the chemical form of energy allocated to growth, survival and reproduction, the free radicals oxidize and thus affect many cellular components such as DNA, proteins and lipids. The ROS overproduction in the organism causes damage that are either reversible while requiring costly repairs in energy (ie restorative protein synthesis) or non-reversible and often deleterious (ie certain DNA mutations). Both types of damage influence the performance of individuals and therefore their fitness.
    The involvement of mitochondrial performances and their impact is studied through internal changes (i.e. aging, disease); or external changes (environmental changes, including those induced by man). The models studied are predominantly ectothermic vertebrates (amphibians, Lepidosauriens) but also some invertebrates (insects).


    Thématiques de recherche: Ecophysiologie ; Bioénergétique Cellulaire et Performances Individuelles ; Thermobiologie ; Sélection Sexuelle

    Je tente de comprendre l’implication des mécanismes physiologiques sur l’organisation des trade-offs entre traits d’histoire de vie à travers trois processus physiologiques à l’échelle de la cellule que sont la consommation d’oxygène, la production d’ATP et la production de radicaux libres (Reactive Oxygen Species : ROS). Alors que l’ATP constitue la forme chimique d’énergie qui est alloué aux postes de croissance, de survie et de reproduction, les radicaux libres oxydent et donc de modifient de nombreux composants cellulaires comme L’ADN, les protéines et les lipides. La surproduction de ROS dans l’organisme engendre des dommages qui sont soit réversibles nécessitant alors des réparations coûteuse en énergie (i.e. synthèse de protéines réparatrices), soit non réversibles et souvent alors délétères (i.e. certaines mutations de l’ADN). Ces deux types de dommages influencent les performances des individus et donc leur fitness. L’implication des performances mitochondriales et de ses conséquences est étudiée à travers des variations internes (sénescence, pathologie) ; ou externes (changements de l’environnement, y compris ceux induits par l’homme). Les modèles utilisés sont majoritairement des vertébrés ectothermes (Amphibiens, Lépidosauriens) mais aussi quelques invertébrés (Insectes).

  • 2023 Barbe, J., Roussel, D., Voituron, Y., 2023 - Effect of physiological hyperthermia on mitochondrial fuel selection in skeletal muscle of birds and mammals. Journal of Thermal Biology. 117, 103719. ⟨10.1016/j.jtherbio.2023.103719⟩

    2023 Barbe, J., Watson, J., Roussel, D., Voituron, Y., 2023 - . The allometry of mitochondrial efficiency is tissue dependent: a comparison between skeletal and cardiac muscles of birds. Journal of Experimental Biology, 226 (23). ⟨10.1242/jeb.246299⟩

    2023 Boël, M., Voituron, Y., Roussel, D., 2023 - Body mass dependence of oxidative phosphorylation efficiency in liver mitochondria from mammals. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 284, pp.111490. ⟨10.1016/j.cbpa.2023.111490⟩.

    2023 Hirose, S., Hesnard, J., Ghazi, N., Roussel, D., Voituron, Y., Cochet-Escartin, O., Rieu, J.P., Anjard, C. Funamoto, K., 2023 - The aerotaxis of Dictyostelium discoideum is independent of mitochondria, nitric oxide and oxidative stress. Frontiers in Cell and Developmental Biology. Sec. Cell Adhesion and Migration, 11:1134011. (10.3389/fcell.2023.1134011)

    2023 Voituron Y., Guillaume O., Dumet A., Zahn S., Criscuolo F. 2023 - Temperature-independent telomere lengthening with age in the long-lived human fish (Proteus anguinus). Proceedings of the Royal Society B, 290(1998) : 20230503. (10.1098/rspb.2023.0503)

    2022 Boël, M., Veyrunes, F., Durieux, A.C., Freyssenet, D., Voituron, Y., Roussel, D., 2022 -  Does high mitochondrial efficiency carry an oxidative cost? The case of the African pygmy mouse (Mus mattheyi). Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 264, pp.111111. ⟨10.1016/j.cbpa.2021.111111⟩

    2022 Thoral, E., Roussel, D., Quispe, L., Voituron, Y., Teulier L., 2022 - Absence of mitochondrial responses in muscles of zebrafish exposed to several heat waves. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, Elsevier, 2022, 274, pp.111299. ⟨10.1016/j.cbpa.2022.111299⟩

    2022 Voituron, Y., Roussel, D., Le Galliard, J.F., Dupoué, A., Romestaing, C., Meylan, S., 2022 - Mitochondrial oxidative phosphorylation response overrides glucocorticoid-induced stress in a reptile. Journal of Comparative Physiology B, 192 (6), pp.765-774. ⟨10.1007/s00360-022-01454-5⟩

    2022 Voituron, Y., Roussel, D.,, Teulier ,L., Vagner, M. Ternon, Q., Romestaing, C., Dubillot, E., Lefrancois, C., 2022 - Warm Acclimation Increases Mitochondrial Efficiency in Fish: A Compensatory Mechanism to Reduce the Demand for Oxygen. Physiological and Biochemical Zoology, 95 (1), pp.15-21. ⟨10.1086/716904⟩

    2020 Boël M., Romestaing C., Duchamp C., Veyrunes F., Renaud S., Roussel D., Voituron Y., 2020 - Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. Journal of Experimental Biology, 223(5), 215558.

    2020 Roussel, D., Voituron, Y., 2020 - Mitochondrial costs of being hot: Effects of acute thermal change on liver bioenergetics in toad (Bufo bufo). Frontiers in Physiology, 11(153):1-10.

    2020 Voituron, Y., Boël, M., Roussel, D., 2020 - Mitochondrial threshold for H2O2 release in skeletal muscle of mammals. Mitochondrion, 54 : 85-91.

    2019 Boël, M., Romestaing, C., Voituron, Y.#, Roussel, D.#, 2019 - Allometry of mitochondrial efficiency is set by metabolic intensity. Proceeding of the Royal Society B. #These authors equally contributed to this work, 286: 20191693 : 1-6.

    2019 Roussel D., Boël M., Mortz M., Romestaing C., Duchamp C., Voituron Y., 2019 - Threshold effect in the H2O2 production of skeletal muscle mitochondria during fasting and refeeding. Journal of Experimental Biology, 222 : 1-8.

    2018 Destoumieux-Garzon, D., Mavingui, P., Boetsch, G., Boissier, J., Darriet, F., Duboz, P., Fritsch, C., Giraudoux, P., Le Roux, F., Morand, S., Paillard, C., Pontier, D., Sueur, C., Voituron, Y., 2018 - The One Health Concept: 10 Years Old and a Long Road Ahead. Frontiers in Veterinary Science, 5(14) : 1-10.

    2018 Teulier, L., Guillard, L., Leon, C., Romestaing, C., Voituron, Y., 2018 - Consequences of electroshock-induced narcosis in fish muscle: from mitochondria to swim performance. Journal of Fish Biology, 92 : 1805-1818

    2017 Lengagne T., Voituron Y., Gomez D., 2017 - Male within-individual variability in a sexual signal component and its impact on female choice. Behavioral Ecology, 28(1) : 108-116.

    2017 Voituron, Y., Josserand, R., Le Galliard, J.F., Haussy, C., Roussel, D., Romestaing, C., Meylan, S., 2017 - Chronic stress, energy transduction and free radical production in a reptile. Oecologia, 185 : 195-203.

    2016 Lardy S., Rey B., Salin K., Voituron Y., Cohas A., 2016 - Beneficial effects of group size on oxidative balance in a wild cooperative breeder. Behavioural Ecology. Behavioural Ecology, 27(6) : 1820-1825.

    2016 Monnin, D., Kremer, N. , Berny, C., Henri, H., Dumet, A., Voituron, Y., Desouhant, E.,Vavre, F., 2016 - Influence of oxidative homeostasis on bacterial density and cost of infection in Drosophila–Wolbachia symbioses. Journal of Evolutionary Biology, 29 : 1211-1222.

    2016 Plantamp, C., Salort, C., Gibert, P., Dumet, A., Mialdea, G., Mondy, N., Voituron, Y., 2016 - All or nothing: Survival, reproduction and oxidative balance in Spotted Wing Drosophila (Drosophila suzukii) in response to cold. Journal of Insect Physiology 89 : 28–36.

    2016 Tattersall, G.J., Roussel, D., Voituron, Y., Teulier, L., 2016 - Novel energy-saving strategies to multiple stressors in birds: the ultradian regulation of body temperature. Proceedings of the Royal Society B, 283, 20161551 : 1-7.

    2015 Lengagne, T., Gomez, T., Josserand, R., Voituron, Y., 2015 - Long Recording Sequences: How to Track the Intra-Individual Variability of Acoustic Signals. PlosOne 10(5): e0123828 : 1-11.

    2015 Rey, B., Pélisson, P.F., Bel-Venner, M.C., Voituron, Y., Venner, S., 2015 - Revisiting the link between breeding effort and oxidative balance through field evaluation of two sympatric sibling insect species. Evolution 69(3) : 815–822.

    2015 Roussel D., Salin K., Dumet A., Romestaing C., Rey B., Voituron Y. 2015 Oxidative phosphorylation efficiency, proton conductance and reactive oxygen species production of liver mitochondria correlates with body mass in frogs. Journal of Experimental Biology. Experimental Biology, 218 : 3222-3228.

    2014 Hemmer-Brepson, C, Replumaz, L, Romestaing, C, Voituron, Y, Daufresne, M., 2014 - Non-stressful temperature effect on oxidative balance and life history traits in adult fish (Oryzias latipes). The Journal of Experimental Biology, 217 : 274-282.

    2013 Brepson, L., Voituron, Y., Lengagne, T., 2013 - Condition-dependent ways to manage acoustic signals under energetic constraint in a tree frog. Behavioral Ecology, 24(2) : 488-496.

    2013 Foray, V., Desouhant, E., Voituron, Y., Larvor, V., Renault, D., Colinet, H., Gibert, P., 2013 - Does cold tolerance plasticity correlate with the thermal environment and metabolic profiles of a parasitoid wasp ? Comparative Biochemistry and Physiology, Part A 164 : 77–83.

    2013 Stahlschmidt, Z.R., Lourdais, O., Lorioux, S., Butler, M.W., Davis, J.R., Salin, K., Voituron, Y., DeNardo, D.F. 2013 - Morphological and physiological changes during reproduction and their relationships to reproductive performance in a capital breeder. Physiological and Biochemical Zoology 86(4), 398-409.

    2012 Brepson, L., Troianowski, M., Voituron, Y., Lengagne, T., 2012 - Cheating for sex: inherent disadvantage or energetic constraint ? Animal Behaviour, 84 : 1253-1260.

    2012 Mondy, N., Rey, B., Voituron, Y., 2012 - The proximal costs of case construction in caddisflies: antioxidant and life history responses. The Journal of Experimental Biology, 215 : 3453-3458.

    2012 Salin, K., Luquet, E., Rey, B., Roussel, D., Voituron, Y., 2012 - Alteration of mitochondrial efficiency affects oxidative balance, development and growth in frog (Rana temporaria) tadpoles. The Journal of Experimental Biology, 215 : 863-869.

    2012 Salin, K., Roussel, D., Rey, B., Voituron, Y., 2012 - David and Goliath : A mitochondrial coupling problem ? Journal of Experimental Zoology, Part A : Ecological Genetics and Physiology 317 : 283-293.

    2012 Voituron, Y., Brepson, L., Richardson, C., Joly, P., Lengagne, T., 2012 - Energetics of calling in the male treefrog Hyla arborea: when being large means being sexy at low cost. Behaviour, 149 : 775–793.


    Walters K.R. Jr., Serianni A.S., Voituron Y., Sformo T., Barnes B.M., Duman J.G. 2011 A Thermal hysteresis-producing xylomannan associated with cold-tolerance is found in diverse taxa. Journal of Comparative Physiology B. 181(5): 631-640.

    Voituron Y., DeFraipont M., Issartel J., Guillaume O., Clobert J. 2011 Extreme lifespan of the human fish (Proteus anguinus): a challenge for ageing mechanisms. Biology Letters. 7(1):105-107.

    Mondy N., Cathalan E., Hemmer C., Voituron Y. 2011 Energetic cost of case construction in a caddis fly, Limnephilus rhombicus: direct impact on larvae and delayed impact on the adult. Journal of Insect Physiology. 57(1):197-202.


    Salin K., Teulier L., Rey B., Rouanet J.L., Voituron Y., Duchamp C., Roussel D. 2010 Tissue variation of mitochondrial oxidative phosphorylation efficiency in cold-acclimated ducklings. Acta Biochimica Polonica. 57(4):409-412.

    Meylan S., Haussy C., Voituron Y. 2010 Physiological actions of corticosterone and its modulation by an immune challenge in reptiles. General and Comparative Endocrinology. 169(2):158-166.

    Salin K., Voituron Y., Mourin J., Hervant F. 2010. Cave colonization without fasting capacities: an example with the fish Astyanax fasciatus mexicanus. Comparative Biochemistry and Physiology A. 156 (4):451-457

    Cote J., Meylan S., Clobert J., Voituron Y. 2010. Carotenoid-based coloration, oxidative stress and corticosterone in common lizards. Journal of Experimental Biology. 213 : 2116-2124.

    Issartel J., Voituron Y., Guillaume O., Clobert J., Hervant F. 2010. Selection of physiological and metabolic adaptations to food deprivation in the Pyrenean newt Calotriton asper during cave colonisation. Comparative Biochemistry and Physiology A. 155: 77-83.


    Voituron Y., Barré H., Ramløv H., Douady C. 2009. Evolution of freeze tolerance: frequency and timing of appearance. Cryobiology. 58(3): 241-247.

    Issartel J., Hervant F., DeFraipont M., Clobert J., Voituron Y. 2009. High anoxia tolerance in the subterranean salamander Proteus anguinus without oxidative stress nor activation of antioxidant defenses during reoxygenation. Journal of Comparative Physiology B. 179(4): 543-551.

    Voituron Y., Paaschburg L., Holmstrup M., Barré H., Ramløv H. 2009. Survival and metabolism of Rana arvalis under freezing. Journal of Comparative Physiology B. 179 (2): 223-230.


    Rey B., Sibille B., Romestaing C., Belouze M., Letexier D., Servais S., Duchamp C., Barré H. Voituron Y. 2008. Reptilian uncoupling protein: functionality and expression under sub-zero temperatures. Journal of Experimental Biology. 211(9):1456-62.

    Voituron Y., Lengagne T. 2008. Freezing before mating severely impacts fitness of a capital breeder. Physiological and Biochemical Zoology. 81 (2): 204-210.


    Issartel J., Voituron Y., Hervant F. 2007. Impact of temperature on the survival, the activity and the metabolism of the cave-dwelling Niphargus virei, the ubiquitous stygobiotic N. rhenorhodanensis and the surface-dwelling Gammarus fossarum. Subterranean Biology. 5: 9- 14.


    Issartel J., Voituron Y., Odagescu V., Baudot A., Guillot G., Ruaud J.P., Renault D., Vernon P. et Hervant F. 2006. Freezing or supercooling: how does an aquatic subterranean crustacean survive exposures at subzero temperatures? Journal of Experimental Biology. 209: 3469-3475.

    Voituron Y., Servais S., Romestaing C., Douki T., Barré H. 2006. Oxidative damage and antioxydant defenses in the European common lizard (Lacerta vivipara) under supercooled and frozen states. Cryobiology. 52 (1): 74-82.


    Issartel J., Renault D., Voituron Y., Bouchereau A., Vernon P., Hervant F. 2005. Metabolic responses to cold in subterranean crustaceans. Journal of Experimental Biology. 208: 2923-2929.

    Voituron Y. 2005. La tolérance au froid chez les reptiles. Bulletin de la Société Herpétologique de France. 113-114 : 53-68.

    Issartel J., Hervant F., Voituron Y., Renault D., Vernon P. 2005. Behavioural, ventilatory and respiratory responses of epigean and hypogean crustaceans to different temperatures. Comparative Biochemistry and Physiology A. 141. 1-7.

    Voituron Y., Joly P. Eugene M. Barre H. 2005. Freeze tolerance of European water frogs: the good, the bad and the ugly. American Journal of Physiology. 288: R1563-1570.


    Voituron Y., Heulin B., Surget-Groba Y. 2004. Comparison of the cold hardiness capacities between oviparous and viviparous strains of Lacerta vivipara. Journal of Experimental Zoology. 301A: 367-373.


    Voituron Y., Eugene M., Barré H. 2003. Survival and metabolic responses to freezing by the water frog Rana ridibunda. Journal of Experimental Zoology. 299A: 118-126.


    Voituron Y., Mouquet N., deMazancourt C. and Clobert J. 2002c. To freeze or not to freeze ? An evolutionary perspective on the cold hardiness strategies of overwintering ectotherms. American Naturalist. 160 (2) :255-270.

    Voituron Y., Verdier B., Grenot C. 2002b. Respiratory metabolism of the European common lizard (Lacerta vivipara) during freezing and supercooling episodes. American Journal of Physiology. 283 : R181-R186.

    Voituron Y., Storey J., Grenot C. and Storey K. 2002a. Freezing survival, ice content and blood composition of the freeze tolerant European Common Lizard, Lacerta vivipara. Journal of Comparative Physiology B. 172 : 71-76.


    Voituron, Y., Hérold, J.P., Grenot, C. 2000. Metabolic adaptations of overwintering european common lizard (Lacerta vivipara). Physiological and Biochemical Zoology 73 (3), 264-270.


    Voituron, Y., Grenot, C. 1999. Effets de la température sur la ventilation chez Lacerta vivipara (Reptilae, Lacertidae). Bulletin de la Société Herpétologique de France 92 (4), 19-28.

Site de la Doua
Université Claude Bernard - Lyon I
CNRS, UMR 5023 - LEHNA (Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés)
3-6, rue Raphaël Dubois - Bâtiments Darwin C & Forel, 69622 Villeurbanne Cedex
43, Boulevard du 11 novembre 1918
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Tél. : (33) 4 72 43 29 53 - Fax : (33) 4 72 43 11 41
Site de Vaulx-en-Velin
CNRS, UMR 5023 - LEHNA (Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés)
3, rue Maurice Audin
69518 Vaulx-en-Velin
Plan d'accès
Tél : (33) 04 72 04 70 56 - Fax : (33) 04 72 04 77 43